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Whole genome and exome sequencing unavoidably generates incidental findings.
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Yet, these new technologies will also generate a vast quantity of data that could be more easily misinterpreted than traditional genetic information and generate incidental findings.
While the clinical history usually obviates the need for brain imaging in RE (especially in the presence of a suggestive EEG), and brain imaging in RE can generate incidental findings, 38 variable clinical features can make an early diagnosis more challenging in PS and might explain the higher frequency of imaging requests.
Including fixed effects in a discrete choice model might generate an incidental parameter problem, which, however, does not occur when using a linear probability model.
Traditionally, experts had argued that the researcher generating an incidental result, or their institutional review board, should take on that duty.
Within the set of Q best matches we have also verified that, in general, the majority of correct correspondences share the top positions of the ranking together with a small number of false matches (generated by incidental signature similarities).
Such information may be the direct result of the research or may be generated as an incidental finding.
In the case of Dp260, Dp140, and G-utrophin, relatively few studies have been performed, and it was until now entirely conceivable that mammal-specific cryptic promoters are responsible for generating transcripts of incidental significance.
Moreover, differences in initial conditioned freezing can be generated by the incidental selection of arbitrary factors unrelated to emotional learning, such as general activity level or sensitivity to the tone or shock.
If we imaginatively combine the findings provided by Henderson et al. with recent studies that demonstrate that incidental findings generated through DNA-based tests are relatively common [ 7], we may conclude that returning incidental findings to 100,000 or 500,000 participants included in a genomic biorepository could represent a remarkably expensive and time-consuming effort.
Clinicians, in the process of shared decision making, should also standardly offer patients the opportunity to opt out of receiving the details of the incidental findings generated in their case, as opposed to being informed of the general fact that such findings exist.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com