Checkpoint mutants fail to detach transcribed genes from nuclear pores, thus generating topological impediments for incoming forks.
This generates confusion and may create unintended impediments for research.
It's an impediment to getting increased funding for infrastructure when federal, state and local governments don't have a fully-developed system in place that generates money from existing facilities and structures.
To overcome this impediment, we generated an experimental copy of the Tex11 gene at an autosomal locus, placing a Tex11 knockin allele under the transcriptional and translational control of Tex19.1 (Chr. 11; Fig 2A).
To determine whether mex3-1 knockdown resulted in a global impediment in generating postmitotic cells, we quantified the proportion of piwi-1−PIWI-1+ cells, which are thought to represent immediate stem cell progeny that have permanently exited the cell cycle.
The revenues to states' coffers generated by racing are one of the impediments to developing a national, centralized racing governance.
Commonly referred to as the Mount Laurel decision, the ruling generated a program that has over the years sought to overcome impediments to this goal, establishing the housing council as the enforcement agency, and creating a way for towns to raise money for new housing through the collection of fees from local builders.
In addition, as more COI sequences are generated from identified adults, this issue will become less of an impediment.
Mr Takamiya says returns on overseas assets at MUFG's biggest bank generate about 2.5%, versus less than 1.5% at home.There are, however, some impediments to growing further in Asia, and especially to catching up with Western competitors such as HSBC and Citigroup.
Because fork advance and the progression of the transcription bubble generate positive supercoiling, a head-on collision between replication and transcription causes topological impediments and fork pausing (Liu and Alberts, 1995; Olavarrieta et al., 2002; Wang, 2002).
