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Hydrophobic C-terminal end-tagging of the cationic sequence RRPRPRPRP generates highly selective AMPs with potent activity against multiresistant bacteria and efficiency in ex vivo wound infection models.
Thus, this protocol generates highly selective phage clones for the target cells without the need for an additional negative selection step.
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She has specialized on generating highly selective MIP materials for ionic analytes.
Antibodies can have exquisite specificity of target recognition and thus generate highly selective outcomes following their systemic administration.
However, due to the challenge in generating highly selective and potent PI3Kγ inhibitors, compound effects could be due to off-target activities.
However, the oxidation of the probe by ClO− perturbs a new equilibrium of the structural interconversion between the nonfluorescent spirolactone and the fluorescent ring-opened zwitterion, which generates a highly selective fluorescent probe for ClO−.
We use a network of resonate-and-fire (RAF) [15] neurons to demonstrate that this mechanism generates a highly selective spatio-temporal firing pattern.
Bio-derived transition-metal complexes containing well-defined and well-characterized active sites can be anchored, in a site-isolated fashion, on to the inner walls of porous inorganic supports, for generating highly active and selective single-site heterogeneous catalysts, which can serve as effective functional mimics of metalloenzymes.
On the basis of this strategy, a highly AT2R-selective (18,000-fold higher selectivity (IC50AT1R/IC50AT2R)) and high affinity agonist analogue (Ki = 3 nM) that exerted antiproliferative activity against MCF-7 breast carcinoma cells was obtained, pointing to a rational way to generate highly receptor subtype-selective drugs.
These patients demonstrate that it is possible for brain damage to generate a highly selective yet general impairment of conceptual knowledge [ 1, 2, 22, 23].
This approach resulted in the discovery of a fragment that was subsequently elaborated to generate a highly selective type II PDK1 kinase inhibitor.
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