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However, much uncertainty exists about the mechanistic links between CFTR mutation and the pleiotropic nature of the resultant multi-organ CF disease [ 4] because F508delCFTR generates apparently unconnected phenotypes such as channelopathies [ 5], dysfunctional pathogen sensing [ 6] and frustrated autophagy [ 7, 8].
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Now, a Japanese team has figured out how to overcome nature's obstacles and has generated apparently normal mice by combining the genomes of two mouse eggs.
Unexpectedly, breeding BcorFl/+ mice to ß-actin-Cre mice generated apparently normal female (BcorΔ3/+) and male (BcorΔ3/Y) mice.
Knockout of either ID1 or ID3 alone in mice generated apparently normal phenotypes [ 31].
It is noteworthy that Src42A or Src64B alone can often generate apparently weaker versions of the N/Src synergistic phenotype.
These tasks have been interpreted as covertly asking participants to generate apparently random response sequences (Roepstorff & Frith, 2004).
This conclusion is strongly supported by the fact that we can generate apparently identical species upon treatment with a bifunctional maleimide.
These multivariate methods are prone to spurious correlations that can generate apparently functional glucose measurements in the complete absence of glucose-specific analytical information (166, 167).
This is a critical stage as, with any prioritisation framework, there will be imperfections in the mechanism which may generate apparently perverse results.
In contrast, occludin-deficient ES cells are able to generate apparently normal cystic embryoid bodies, normal appearing tight junction strands, and normal concentration of ZO-1 atightht junctions (Saitou et al. 1998).
We refer to these as biases because any correlation between the prevalence of genes in a dataset and their prevalence within GO (number of annotations) will generate apparently effective GBA in which a subset of genes or connection will dominate results with either little specificity or little generalizability.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com