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To overcome this impediment, we generated an experimental copy of the Tex11 gene at an autosomal locus, placing a Tex11 knockin allele under the transcriptional and translational control of Tex19.1 (Chr. 11; Fig 2A).
This explosion of biomedical resources generates impediments for the biomedical researchers' needs, in order to efficiently discover appropriate resources to accomplish their clinical tasks.
Whereas the former studies indicate that the insulator forms a physical impediment to activation of Igf2, the latter posits that enhancer-blocking is the result of direct interaction with the enhancers and inactive promoter, generating a transcriptionally unproductive association.
Checkpoint mutants fail to detach transcribed genes from nuclear pores, thus generating topological impediments for incoming forks.
In addition, as more COI sequences are generated from identified adults, this issue will become less of an impediment.
We now know that this degradation is not only to remove an impediment to migration, but that it is also a process in which morphoregulatory signals are generated and/or quenched through remodeling.
It's an impediment to getting increased funding for infrastructure when federal, state and local governments don't have a fully-developed system in place that generates money from existing facilities and structures.
Facts can become an impediment.
Parents are an impediment.
It may even prove an impediment.
So cost should not be an impediment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com