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In physiological conditions there is a tight balance between the generation of these different agents, and any disturbance in this equilibrium generates a pathological condition denominated endothelial dysfunction.
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As result, the damaging stimulus generated a pathological state in the rat paw, histologically characterized by edema, hemorrhage, and inflammatory infiltration at 24 h after treatment.
The pelvic musculature undergoes tonic contraction as a result of limbic efferent stimulation, which produces the minimal changes found on pathological examination, and generates a further sensation of pain.
Studies on a larger number of prostate samples, including both neoplastic and non-cancerous prostate, would further clarify this issue and should generate a link between the pathological cascade including infection, inflammatory response and amyloid deposition with benign and malignant transformations in the prostate gland.
All of these findings suggest that those diverse pathological contexts that generate a regulation IIS response might be revisited under the light of a putative tolerant process.
The purpose of the present study was to investigate the cardiospecificity of LXRα in modulation of myocardial metabolism and pathological hypertrophy by generating a murine model of cardiac-specific LXRα overexpression.
This has allowed us to localize biological factors which modulate neurogenesis under pathological conditions and to generate a mathematical analysis for neuroblast behavior on the basis of biological observations.
We generated a human neuronal model and investigated the pathological phenotypes of human neurons containing GGGGCC repeat expansions.
In aging cells or under unfavorable cellular conditions, misfolding of proteins generates common pathological events linked with neurodegenerative diseases and aging.
Pleiotropy in diseases often occurs when an impaired gene generates pathological effects on some molecular-associated diseases simultaneously.
Histone posttranslational modifications (hPTMs) generate a complex combinatorial code that plays a critical role in the regulation of gene activity and nuclear architecture during physiological and pathological processes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com