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This generated a steric hindrance impairing LVX interaction with GyrA catalytic site.
The chosen site, away from both the C-terminal peroxisomal targeting sequence and the active site, is predicted to accommodate the tag without generating significant steric hindrance.
Rictor and mSin1 together generate steric hindrance to inhibit binding of FKBP12-rapamycin to mTOR, revealing the mechanism for rapamycin insensitivity of mTORC2.
Structural analysis indicates that FKBP12-Rapamycin may generate steric hindrance for substrate entry to the catalytic cavity of mTORC1.
Substitution by a valine could generate steric hindrance and this could explain why this mutation is known to increase quinolone resistance [42].
They can generate important steric hindrance in the vicinity of receptors, and thus, adequate controls are needed to correctly interpret receptor oligomerization.
They must be allowed to complete their inspections without hindrance.
So they flow through Earth's magnetic field without hindrance.
Now that he can breathe without hindrance, he may have more potential than some others.
Northern Ireland businesses invest without hindrance in the Republic and the same occurs for businesses in reverse.
Openly gay soldiers now serve without hindrance in all branches of the military.
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