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Despite the growing consensus that genetic results generated through either clinical or research tests should be reported to providers and patients when they are considered actionable, there remains controversy over the precise criterion that should be used in identifying when a result meets this standard.
These libraries can be generated through either biological [8], [9], [10] or chemical means [11], [12].
Superoxide is generated through either incomplete reduction of oxygen in electron transport systems or as a specific product of enzymatic systems, while NO is generated by a series of specific enzymes (the nitric oxide synthases).
In the case of haematological cancers, its pathogenic effects are mediated via the expression of hyperactive truncated forms, generated through either somatic mutation or disrupted splicing (Liongue et al, 2009b).
In addition to the membrane-bound receptor, a soluble form of the IL-6Rα chain can be generated through either alternative splicing or proteolytic cleavage and is capable of binding to IL-6 and activating cells through association with gp130 (Kamimura et al., 2003).
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"What we are not prepared to happen, and I am sure our fans will appreciate this, is allow our rival clubs in England and Europe to gain a competitive advantage over us in terms of the revenue they can generate through either expanding the capacity of their existing stadia or moving to a new stadium and then invest that upside in their team or the club.
In this way, the databases generated through use of either of the investigated next-generation sequencing approaches have been validated and appear reliable and reproducible.
If tagged PCR products targeting multiple different genetic regions are also pooled (either generated through single- or multiplex PCR assays), then clearly the number of products in a single reaction increases dramatically.
DNA is attacked principally by OH radicals, and a variety of products can be generated through reactions with either the DNA bases or the deoxyribose sugars.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com