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Mathematical modeling of apoptosis signaling reaches back more than a decade ago when Fussenegger et al. generated the first model of apoptosis [ 70].
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We introduced a single-nucleotide mutation identified in human FD patients into the murine Asah1 gene to generate the first model of systemic ACDase deficiency.
The first model of GmRLK18-1 structure was generated using the RAMP software suite of programs (http://compbio.washington.edu; http://protinfo.compbio.washington.edu).edu
In this study, we generated the first human model of CPVT.
By threading modeling, we generated the first theoretical models of LTR-RTE proteins in plants.
Thus we have generated the first conditional model for metastasis of NSCLC and identified a gene, c-MYC that is able to orchestrate all steps of this process.
We have generated the first in vivo model of liver tumorigenesis driven by transgenic overexpression of oncogenic kras V12 in zebrafish.
In 2003, von Hörsten and coworkers generated the first transgenic rat model of HD (tgHD51 rats; Sprague-Dawley background), which carries a truncated htt cDNA fragment with 51 CAG repeats under the control of the native rat htt promoter [ 20].
We have studied the structure of the TatAd complex from Bacillus subtilis using electron microscopy to generate the first 3D model of a TatA complex from a Gram-positive bacterium.
To test these both models, we generated the first genetic maps of Oenothera species using amplified fragment length polymorphism (AFLP) and derived complementary DNA markers (Bensch and Akesson, 2005, Meudt and Clarke, 2007).
Two sets of models are generated, the first relating ground estimates of AGB to airborne laser scanning (ALS) measurements and the second set relating ALS estimates of AGB (generated using the first model set) to GLAS measurements.
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