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Additionally substance data can be matched against in-silico generated tandem mass spectra [5] or can be used in approaches using substructure detection algorithms and molecular isomer generators [6].
Higher NCE generated tandem spectra that were too complex for identification.
Even large in silico generated tandem mass spectral libraries such as LipidBlast cannot cover all known lipid classes.
We here show the versatility of in-silico or computer generated tandem mass spectra that are directly obtained from compound structures.
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We then tested whether simply generating tandem repeats of short, aggregation-prone segments within these domains would likewise be sufficient to create prion activity.
Recently, Bergeron and colleagues demonstrated that hydroxyl radicals generate tandem lesions composed of 8-oxodG and an adjacent oxidized pyrimidine [14].
In addition to whole genome events, small local events can generate tandem duplicated genes which are often considered younger than segmental duplicated genes obtained from a whole genome duplication [1], [5].
Such patterns suggest local gene duplications generating tandem repeats [ 39].
used circularized genomic RNA fragments to generate tandem repeats which originate from a single individual within the viral population.
Reversed Ac ends transposition (RET) during DNA replication generates Tandem Direct Duplication (TDD) and Composite Insertion (CI).
Here we will emphasize those CNV events that affect alterations in a pre-existing tandem array or that generate tandem duplications of single-copy genomic sequences.
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