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This problem is solved by imposing spatial smoothness on the generated reconstruction as discussed next.
This is achieved by comparing the generated reconstruction against a ground truth estimate.
The result is an averaging-like effect in the generated reconstruction.
It's actually more complicated than that, because the game is set in the 25th century and you're trying to rescue a computer generated reconstruction of the fictional "real" Lumi from far in the game's past (which is our future, Lumi having been born in, I dunno, 2017 or something?)… and I'm going to stop talking about the story now.
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Both models consistently perform better than randomly generated reconstructions.
We generated reconstructions of smooth muscle myosin S1 carrying the R403Q mutation attached to actin filaments using electron cryomicroscopy and image analysis.
DR drafted the manuscript, carried out the experiments, including the microscopic observations and computer generated reconstructions.
From the generated reconstructions, the number of (predicted) fragmentation sites and the number of correct fragmentation sites are counted.
We replaced the scoring function of UniNovo with that of MS-GFDB and generated reconstructions using the replaced scoring method.
25– 28 By performing a global structure optimization of the KTaO3 surface, we show that a reconstruction of the TaO2 terminated surface, results in a set of surfaces that are more stable than any generated reconstructions of the KO terminated surface, including those previously considered.
This situation has driven the development of a range of software tools that seek to automate parts of the process to generate reconstruction content, e.g., [8].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com