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Note for later that we have two ways to retrieve the dissociation constants: first, using the EC50 (efficient concentration 50) that is the amount of ligand needed to generate occupation of half the receptors at equilibrium.
While the mechanism for this distinction at mGlu7 is not known, it has been proposed that the enhanced potency and selectivity of LSP4-2022 at mGlu4 is generated by occupation of an additional binding pocket in the N-terminal domain.
Despite his many other accomplishments, Butler gained and has retained his historical notoriety as a result of the controversies generated during his occupation of New Orleans.
The presence of Pt on the ZnO surface generated a greater occupation of the O 2p orbitals and so a greater negative effective charge of the O ions than Au and Ag nanoparticles.
While a number of self-styled militia groups had rallied to Bundy's cause, the occupation generated little sympathy from authorities in nearby Harney County.
A specific questionnaire was devised to characterise the centre's ability to generate meaningful occupations for the attendees.
A total of 146 (45%) patients with FM were working at the time of the study and 156 (48%) had previously had an income-generated occupation.
Using water along the transmission line and the level of profits thus generated (C7): The main occupation of the villagers is livestock breeding and the major part of the landscape close to this village consists of seasonal grasslands where sheep graze.
He absorbed and became a part of the major cultural currents generated by the U.S. occupation, notably the teachings of the great Haitian thinker Jean-Price Mars, and wrote historical and ethnological studies.
Figure 8B clearly shows that in the G232V mutant, the valine side chain protrudes into the ligand channel at the location of the Xe6 binding site (behind the magenta F228), narrowing the mutant ligand channel slightly at this location to 4.2 Å from 6.6 Å in the wild-type enzyme; these distances are obtained by measuring the diameter of the cavity generated from the O2 occupation data.
In the same time, EPI would induce a steric hindrance inside the general cavity and cloxacillin would generate a competitive occupation of a ß-lactam affinity site [22].
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