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Most patients participating in clinical trials are in the advanced stages of this progression (i.e., with atherosclerosis or cardiovascular disease) and the "positive feedback loop" will have generated irreversible structural changes such as vascular remodeling or atherosclerosis.
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So, gas producing rate should be kept in a reasonable speed, or it may generate irreversible permeability harm.
Surgical and radiotherapeutic procedures generate irreversible effects on normal tissues, involving injuries on their reparation properties, especially on bone.
In severe cases, an accident caused by interference or attack may generate irreversible economic loss or create a significant threat to individual safety.
Here, we describe disulfide trapping, a methodology for generating irreversible covalent binary protein complexes from unbound protein partners by introducing two cysteine residues, one per interaction partner, at selected positions within their interaction interface.
In order to describe measurement as a real dynamical process generating irreversible facts, Wigner called for some nonlinear modification of (2) to replace von Neumann's projection (1).[9] Since the 1980s, Stapp has developed his own point of view on the background of von Neumann and Wigner.
Over the past several years, major progress has been made in generating irreversible inhibitors targeting the PADs.
Epoxomicin is a specific and irreversible inhibitor of the proteasome that forms a covalent adduct with the amino terminal Thr of the 20S proteasome catalytic subunits, generating irreversible morpholino adducts.
In this case, past toxicological experience may support the threshold hypothesis, whereas other lines of evidence (such as the proposed molecular mechanisms by which EDCs could disrupt development and generate irreversible effects on endocrine-sensitive organs) support the no-threshold hypothesis.
In animal models of orthotopic ovarian cancer pretreated with PEG-NRs, delivery of NIR light via the implanted device selectively elevated the temperature of ovarian tumors relative to background tissue without generating irreversible tissue damage and enhanced the delivery of diagnostic and therapeutic agents.
Conversely, TDRLs generate "generally irreversible" rearrangements and can be used to identify which of the transformational pathways listed above are plesiomorphic or apomorphic (Perseke et al. 2008).
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