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Illumination generated inward currents that were maintained for the duration of the stimulus with only minor channel inactivation (Fig. 1B, C).
When clamped at the chloride reversal potential, IC cells generated inward currents during locomotion.
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Whole-cell patch recording studies showed that spiral ganglion neurons respond to protons and generate inward currents.
Similarly, fast reapplication of Cu-Phen during hyperpolarization to −140 mV did not generate inward currents (black trace after the arrow).
Moreover, B10 cells expressing NF proteins were identified to generate inward currents of voltage-activated Na+ channels, which indicate that the neuronally differentiated B10 cells have electrophysiological characteristics of mature neurons.
The closed state constraint of C136 in S1 is appealing when considering a recent work performed in Shaker channels which showed that a histidine mutant of I241 (equivalent of C136 in Kv7.1) generates inward currents at hyperpolarized potentials (closed state), suggesting that it forms part of a hydrophobic plug that splits the water-accessible crevices [15].
Both isoforms generate inward rectifying K+ currents blocked by E-4031, a selective hERG blocker.
Cells were voltage clamped at −75mV, a potential at which the chloride-conducting glycine receptors generate inward currents.
Recent data, obtained using giant uni-lamellar vesicles, suggests that ESCRT-I and II are necessary to generate inward budding vesicles at the endosomal membrane.
Libraries were constructed using the TruSeq RNA Sample Prep kit (Illumina, San Diego, CA, USA) and sequenced using a HiSeq 2000 (Illumina) to generate inward paired-end reads of 100 bp.
In the limit of an in finitely large binding a finity where the PFK activation is described by a Hill function, as in Sel'kov model [ 12], the capability to generate inward propagating waves is lost.
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CEO of Professional Science Editing for Scientists @ prosciediting.com