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By splicing precursor (pre-) mRNAs in different ways, multiple mRNAs and proteins can be generated from a single gene.
Palladin exists in all vertebrates as multiple size variants generated from a single gene that possesses alternative promoters, i.e. a "nested gene".
Biologically, multiple transcripts can be generated from a single gene by alternative splicing (AS).
Interestingly, the mitochondrial and cytosolic isoforms of ISCU are generated from a single gene through alternative splicing, and similarly, the mitochondrial and cytosolic isoforms of NFU are also generated from a single gene by alternative splicing products.
Alternative splicing is a process whereby distinct mRNA transcripts are generated from a single gene so that the resulting splice variants can be translated into different protein isoforms.
Multiple variants of proteins or transcripts can be generated from a single gene via alternative splicing, thus increasing the complexity of proteome and transcriptome.
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By splicing several combinations of exons into different transcripts, AS generates, from a single gene, multiple isoforms of a protein with potentially diverse functions.
The large number of reads generated from a single sample allow researchers to study the genes being expressed and estimate their expression levels, and to discover alternative splicing and other sequence variations.
Hundreds to thousands of candidate genes, or genes of interest, can now be generated from a single experiment utilizing high throughput screening technologies.
Fibroblasts were generated from a single normal control individual and a PD subject harboring a c.1858G>A, p.Asp620Asn mutation in the VPS35 gene, as described (33).
The elastin fiber, generated from a single human gene elastin, is a self assembling integral protein that endows critical mechanical proprieties to elastic tissues and organs such as the skin, lungs, and arteries.
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