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The other possible explanation is that 'clusters' in Illumina chemistry might not be generated evenly on a flow cell because of variable fragment lengths, although the total size of the output does not differ among sequencer runs for libraries with different fragment length distributions.
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With the help of boundary-distance maps, algorithms are investigated to generate evenly distributed spiral curves on the surface.
The parameter identification procedure uses a micromechanical model to generate evenly distributed reference points in the full space of possible loading modes.
For each species, we randomly selected 10 individuals to generate evenly sampled (in terms of the number of individuals per species) datasets.
One common characteristic shared by Chd1 and many but not all ISWI-type remodelers is the ability to generate evenly spaced arrays both in vitro and in vivo.
This sensitivity to linker DNA is believed to underlie their ability to generate evenly spaced nucleosomal arrays (Gelbart et al., 2001; Stockdale et al., 2006).
Genome-wide nucleosome mapping in budding yeast revealed that deletion of ISWI in yeast disrupts nucleosome spacing (Gkikopoulos et al., 2011), suggesting that ISW1 remodelers are key players in generating evenly distributed nucleosomal arrays.
Recent studies of the nucleosome repositioning activity of the ISWI-containing remodeling complex ACF have suggested that the dependence of the affinity of ACF for nucleosomes on the length of the DNA flanking the core particle results in ACF generating evenly spaced nucleosome arrays.
For example, in the case of the ISWI protein, accessory subunits such as Acf1 can alter the directionality of repositioning and increase the efficiency of generating evenly spaced chromatin (Eberharter et al., 2001; Fyodorov et al., 2004; He et al., 2006).
The job opportunities that O'Reilly heralded are generated, fairly evenly, by the federal government, the oil industry, and everything else.
Meanwhile, states like Michigan generate revenue evenly across all sins.
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