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We used HS outbred mice to perform a stringent association test, in which the effect of Comt1 B2i locus is examined against a large panel of different highly heterozygous genetic backgrounds, generated by over 65 generations of accumulated recombination from eight inbred progenitor strains (Boulder Heterogeneous Stock, McClearn & Hofer 1999).
Bevi's smart water dispensers, which provide customizable flavors using filtered tap water and natural ingredients, have saved the waste generated by over 65 million plastic bottles.
According to a recent study, annual carbon emissions from the tar sands alone would be equivalent to that generated by over 50 coal fired power stations.
Therefore there might be a direct involvement by the AEFLL in the inhibition of DNA and lipid oxidation by peroxynitrite anion (ONOO−) which are generated by over production of nitric oxide and the superoxide anion.
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The regions are adjacent and with small overlapped boundary to eliminate noise generated by over-exposure.
Animal models of neurodegenerative disorders are generated by over-expression of causal genes, further supporting the conclusion that increased gene expression is related to pathogenesis [7].
Indirect data generated by over-expression of a dominant-negative N-cadherin or targeting p120-catenin suggest an important role in intestinal homeostasis [14], [15].
Alternatively, very high levels of Cofilin, generated by over-expression experiments in mammalian cells or in this study with transgenic animals, can exceed the capacity of Capulet to recycle Cofilin depolymerizing activity, leading to self-assembly of actin-bound Cofilin into AC rods.
CkbTg mice were generated by over-expression of Ckb under control of the human CD2 promoter and locus control region in the transgenic expression vector p29△2 (gift of Paul Love), two transgenic founders with similar phenotype were generated and one line was used in this study.
Engineered cell models (ECMs) generated by over-expressing 35S:: CrtB in citrus embryogenic calli show a striking accumulation of carotenoids [ 28].
To ensure fluidic isolation between compartments, a hydrostatic pressure difference was generated by over-pressurizing the non-treated chamber as described in [ 21].
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