Sentence examples for generated by methylation from inspiring English sources

A comparison of the REs and the Alu subfamily consensus sequences showed that the CG dimers frequently occur at positions corresponding to the CA TG dimers in the p53 core motifs, indicating that these sites could be generated by methylation and deamination of CpG, as was proposed by Zemojtel et al. [ 36].

Some recent publications have added data on natural epigenetic variation in animal and plant species by sampling cytosine methylation using Methylation-Sensitive Amplification Polymorphism (MSAP) technology [ 36- 38], a modification to the original AFLP protocol that compares product profiles generated by methylation-sensitive/insensitive isoschizomers.

Genome-wide DNA methylation profiles were generated by determining methylation levels for each cytosine in the genome.

While CpG methylation has been associated with well defined regulatory processes such as parental imprinting and X chromosome inactivation [18] and the compact chromatine structure generated by DNA methylation is generally thought to be associated with transcriptional silencing.

The artificial mono- and di-methylation sites on lysine and arginine residues were generated by simulated methylation on theoretical unmodified peptides.

The primers used for amplification of the top strand were manually designed to avoid bias generated by asymmetric methylation.

The capacity of 5-AzaC to inhibit methyltransferase activity led to the expectation that profiles generated by the methylation-sensitive HpaII and MspI would diverge in untreated samples (since methylation will disproportionally affect the former profiles) but converge in treated samples (since the DNA templates lack the methylation that cause the difference).

The method compares the yield from two samples of size-selected fragments generated by a methylation-sensitive restriction enzyme.

To validate the DNA methylation data generated by BeadArray technology, methylation-specific-PCR (MSP) of 12 genes were performed as previously described [10], [19], [20], [21], [22], [56], [57], [58].

First, we address whether the association between CpG islands (CGIs) and recombination hotspots is generated by lack of methylation, GC-biased gene conversion (gBGC), or both.

De novo methylation in plants is generated by the RNA directed DNA methylation (RdDM) pathway where 24 nt siRNAs target regions of the genome for methylation (reviewed in ref. 10).