The presence of the CA IX/XPO1 complexes, highly enriched in extrachromatinic nucleolar sites, was consistently associated with decreased transcription of 45S rDNA genes, both in hypoxic cells and in cells treated with acetazolamide, in which cellular acidosis was generated, as a consequence of general CA inhibition.
In concert, these findings inform a general argument that hydrologic fragmentation and the novel ecosystems generated as a consequence drives widespread evolutionary divergence in a variety of wild fish populations.
In the past 25 years, more than 4,500 firms have been spun out from non-profit research institutes, based on patents generated as a consequence of this law.Scores of medical advances and technical innovations have resulted, including MRI body scanning, the vaccine for hepatitis B, the atomic-force microscope and even the technique behind Google's search engine.
Most notably, a majority of research has focused on emotions generated as a consequence of inadequate sleep rather than underlying regulatory processes that may alter these experiences.
This inotropic effect was significantly higher in the guinea pig than in the rat and was strictly related to the amount of superoxide anion (O2−), generated as a consequence of cardiac menadione metabolism through mitochondrial NADH-ubiquinone oxidoreductase.
For example, it could mean that compounds have been extracted from some hitherto overlooked important source or, on the other hand, could have been generated as a consequence of heterogeneity and/or errors in structural representation.
On the contrary, evidence from several countries suggests that serotype replacement in carriage generates as a consequence of vaccination [ 9- 12].
This is not surprising, but rather provides further support to the two-hit hypothesis, which predicts that renal cystogenesis generates as a consequence of loss of the normal copy of the PKD1 gene.
Of particular concern for NHP is the volume of food waste that is generated daily as a consequence of normal foraging behavior in these species.
However, they were not observed in cells treated with PS2, showing that they were not generated solely as a consequence of inhibiting proteasomal degradation.
These phenotypes can be explained by the almost complete absence of replication forks in these mutants, which means that no S phase checkpoint can be generated and, as a consequence, cells enter mitosis on schedule but with unreplicated DNA.
