A modestly successful strategy has evolved over the last couple of decades based on development of scoring functions (e.g. mimicking free energy) that can capture native or native-like structures from an ensemble of decoys generated as plausible candidates for the native structure.
According to Cong et al., IncRepair achieves a good accuracy with (k=1) or 2. As we increase parameter k, the algorithm's computational cost increases exponentially, since it generates as many candidates fixes vs as the combination of (texttt {dom}(C))s.
A set of candidate compounds was then generated as a first pass and errors on the m/ z and retention time assignments were provided for each compound.
As a consequence, among 820 ingredients from 421 herbs, a ranking list of 305 ingredients was generated as candidate agonists of PXR.
In the first step, maximal k-connected subgraphs for various k are generated as candidate complexes.
The third heuristic is a mutation based algorithm that considers a randomly generated input sequence as a candidate solution, and if the candidate is not a distinguishing sequence, then the algorithm tries to find a solution by appropriately mutating the considered candidate.
I cannot recall a president who generated so much excitement as a candidate but who turned out to be such a political dud as chief executive.
In exploratory analysis, we applied Partek's single-level cross-validation method (Partek® software, Partek Inc., St . Louis MO) using a portion of the samples in each group as training dataset to generate a candidate signature gene list, and tested them on the rest of the arrays as the testing dataset to evaluate if the gene list would correctly identify array's group.
The training samples were generated as follows: for each gene ID candidate, if the ID appears in the manual annotation list, the candidate is taken as positive, otherwise negative.
Its templates are more narrowly tailored to specific types of real-world patches, so it doesn't generate as many useless candidates.
