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The randomisation sequence was generated and administered at an independent clinical trials unit (York, UK) to ensure that allocation was concealed.
Randomisation was stratified by centre (five centres) and by surgical procedure (fasciectomy or dermofasciectomy) in block lengths of 4. The allocation sequence was generated and administered independently through a central telephone randomisation service at the Clinical Trials Unit, University of East Anglia.
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Current investigation seeks to improve the methods for generating and administering the lymphocyte cultures, and future clinical trials aim to improve durable response rates and extend the patient populations that are candidates for treatment.
Typically, septic patients show marked hyporeactivity to both endogenously generated and exogenously administered vasoconstrictors [ 1, 2].
In all pediatric patients receiving haploidentical HSCT, HCMV- EBV- and adenovirus- specific donor derived CTLs are generated before transplantation and administered in case of refractory infections [ 10, 15].
Perhaps the contradictory reports on the effects of NO in inflammatory joint disease may be reconciled by recognizing that NO likely has differential functions depending on the stage of the disease, the amount of NO generated or administered, and the tissues or cell types affected.
All indices are clinically generated and it is easy to administer.
CS was generated with ANL-926 (Med) and administered through speakers mounted on the left wall of the chambers, controlled by an IBM-PC running MED-PC 4 (Med).
AnxA1 and SuperAnxA1 were generated as recently described 26 and administered intraperitoneally, from day 2, at 1 µg per mouse.
In the 1980s, the virus was characterized, and researchers speculated that it was related to a reassortant influenza A(H1N1) virus vaccine strain, A/PR-8/34 + A/USSR/77, generated in a Soviet laboratory and administered to humans in Mongolia and possibly transmitted from vaccinated humans to camels in a reactivated form (5, 6 ).
The allocation sequence will be generated using secure, online randomisation via a distant computer generated system administered by The University of York.
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