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Alteration of the template region in vivo generated altered telomerase products.
Moreover, no unexpected RT-PCR products were detected, suggesting that no alternative splicing occurred that could have generated altered AUG codon-usage ratios.
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Classical chemical mutagenesis screens efficiently generate altered genetic loci but molecular characterization of the altered loci remains relatively slow and arduous.
Changes in the temporality of human activity inevitably generate altered experiences of space or territory.
Changes in blood flow, thus generating altered hemodynamic forces are responsible for acute vessel tone regulation, the development of blood vessel structure during embryogenesis and early growth, as well as chronic remodeling and generation of adult blood vessels.
Extracellular stimulants induce various cellular responses by regulating diverse pathways, and perturbation of any genes in the pathway can generate altered regulation of signaling networks.
This could generate altered molecular processes regulating similar developmental processes in a species specific manner.
These experiments demonstrate that enzyme recruitment is a powerful tool for adapting to new environmental challenges and for generating altered metabolism.
The relatively different structure of tipranavir, not only generates altered binding profiles but also, causes the unpredictable side effects, such as hemorrhage.
Two mechanical (at DESC/ESTEC in Noordwijk, The Netherlands) and one magnetic (at the University of Nottingham in the United Kingdom) GBFs have been used to generate altered gravity conditions.
The Xenopus TBP (pSP64A-xTBP) [ 15] and TBP2 (pT7TSA-xTBP2) [ 8] constructs were utilized to generate altered binding specificity mutant versions of these proteins by introducing three point mutations in the carboxy-terminal domain of xTBP (I250F, V259T and L261V) and xTBP2 (I273F, V282T and L282V) using the Quick Change site-directed mutagenesis kit (Stratagene).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com