We generated a panel of first and affinity matured second-generation single-chain Fragment variable (scFv) binders specifically binding to human ΔNΔC-VEGF-C and were able to show that these scFv block the binding of VEGF-C to both VEGF-R2 and -3.
Next, we generated a panel of humanized scFvs and tested in vitro for their ability to direct CAR-T cells to specifically lyse, proliferate, and secrete cytokines in response to antigen-bearing targets.
We describe a panel of patient-derived xenografts representing multiple TNBC subtypes and use them to test preclinical drug efficacy of two mTOR inhibitors, sirolimus (rapamycin) and temsirolimus (CCI-779).We generated a panel of seven patient-derived orthotopic xenografts from six primary TNBC tumors and one metastasis.
In the present study, we generated a panel of five monoclonal antibodies (mAbs) which specifically recognized the HIV-1 gp41 6-HB formed by the NHR-peptide N36 and CHR-peptide C34 mixture, but did not react with the isolated peptides N36 and C34.
To determine the role of FXYD6 in tumor progression, we firstly generated a panel of mouse mAbs (monoclonal antibody).
We generated a panel of ATRX fragments spanning 1,188 1,326 and examined their binding capacities with DAXXDHB (Fig. S1B).
To identify molecules that regulate Schwann cell migration, we have generated a panel of monoclonal antibodies against Schwann cell surface antigens that modulate Schwann cell migration in in vitro bioassays.
To explore the functional roles of EB1 phosphorylation, we generated a panel of phospho-deficient (mutation of serine and threonine to alanines and mutation of tyrosine to phenylalanine) and phospho-mimic (mutation of serine, threonine, and tyrosine to aspartic acids) mutants.
We generated a panel of DNA aptamers with diverse binding patterns to colorectal cancer cell lines.
Accordingly, we generated a panel of CEACAM1-constructs with a varying number of extracellular domains (Fig. 6A).
Previously, we generated a panel of recombinant mannosylated proteins (summarized in Table 1) using the yeast P. pastoris [18].
