This association may be due to the fact that the predominance of Th2 cytokines may lead to immunoparalysis that generates a higher incidence of nosocomial infection, worsening prognosis.
In this context, it is not surprising that cardiac surgery generates a higher incidence of AF, and several data support this assumption.
Transgenic mice overexpressing oncogenes involved in human breast cancer, such as HER-2/ Neu, Wnt1 and c- myc, have been generated that develop a high incidence of sporadic mammary carcinomas.
We attempted to generate Tax transgenic mice using the BALB/c background (backcross generation 8: N8); however, we did not observe a high incidence of arthropathy by 24 months of age (data not shown).
In those who do get symptoms however, there is a high death rate, and a high incidence of permanent brain damage (approximately 30percentnt).
This carcinogen generates fibrosarcomas when injected intramuscularly in mice, and tumors carry frequent oncogenic mutations in K-Ras or N-Ras [28], [39] [41], together with a high incidence of p53 inactivation by deletion or point mutation [41], [42].
There are also animal welfare issues: "there's a high incidence of cannibalism in cage-free systems, and also high incidence of bone breakage," he says.
As she remarks, "There was a high incidence of the 'Three A's': adultery, alcoholism and antiquing".
De Maria spent years searching for an appropriate spot, somewhere with a high incidence of storms.
