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That would have generated a gain of more than $1 million.
Metropolitan West Total Return fund, one of the largest actively managed bond funds, generated a gain of nearly 4.5percentt in the first half of the year.
The coarsening approach generated a gain of two and a half orders of magnitude in terms of computational time and an order of magnitude gain in system size (equivalent to ∼ 360,000 atomistic model) while retaining the physical characteristics specific to the piezoelectric polymer.
In the present study, we have generated a "gain of function" mouse model to further understand the in vivo roles of Gasp1.
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Initially, reports suggested that disease-related mutations in SPT1 generated a gain-of-function mechanism in SPT resulting in increased cellular glucosylceramide levels (7).
To further address the role of GASP1 during mouse development and in adulthood, we generated a gain-of-function transgenic mouse model that overexpresses Gasp1 under transcriptional control of the human cytomegalovirus immediate-early promoter/enhancer.
We determined the importance of this spatial restriction of HH signaling activity by generating a gain-of-function model in which HH signaling is ectopically activated in the cortical ureteric epithelium.
Mutation of this residue to asparagine, however, generates a gain-of-function phenotype.
Any new LSG generated should typically be initially non-essential, unless its genesis generates a gain-of-function essential phenotype in rare instances.
Mutation of ALK at position 1174 F1174II) generates a gain-of-function receptor capable of activating intracellular targets such as ERK (extracellular signal regulated kinase) and STAT3 (signal transducer and activator of transcription 3) in a ligand-independent manner.
Alternatively or additionally, the pH-dependent BL-induced BRI1LRR-BAK1LRR interaction may also be associated with conformations of the residues surrounding BAK1Asp122 that generates a gain-of-function phenotype when mutated to asparagine.
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