We generated the trial outcome based on a normal distribution with mean δi and variance 2 σ/ n i = 2/ n i. c.
The software CycDesigN 4.0 (VSN International Ltd ,Hemel Hempstead, UK) was used to generate the design each trial year.
This is done according to a computer generated randomization list, generated by the trial statistician.
A UBC statistician independent of the trial will generate the randomisation sequence; permuted blocks of varying size will be employed to ensure balance over time.
The trial will generate the required evidence, however, cost-effectiveness in the use of expensive technologies is heavily dependent on how much devices are used and the proportion of patients who benefit.
The pilot study will be deemed feasible if the number of eligible, randomised and retained cases within the pilot trial generate the required sample size within a 12 month period of recruitment.
An online web tool is provided for users who can generate the design, conduct clinical trials, and examine operating characteristics of the designs.
The Livopan study is designed as an observational study but randomised controlled trials generate the most reliable evidence of intervention efficacy.
Although randomised controlled trials generate the most reliable evidence of intervention efficacy, the project described here develops the intervention as well as procedures to monitor implementation fidelity of the intervention.
The outcome of the CAROLINA trial may generate the most robust evidence in the decision-making process for selecting a second glucose-lowering agent after metformin in T2D.
