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We hope that the study will generate sufficient evidence that melatonin may be effective; to support a funding application for a larger randomised controlled trial.
If these exploratory and other studies generate sufficient evidence in support of specific hypotheses, case control and/or cohort studies can then be used to test these hypotheses with use of purpose-collected individual-level data.
UNICEF country offices that are piloting innovation programmes will now be able to apply to access the Innovation Fund – a pooled funding mechanism – which will allow them to generate sufficient evidence and results to facilitate the expansion of the programme across countries or regions.
In particular, attention has been given to how promising new approaches supported by pre-clinical data can cross the so-called valley of death and generate sufficient evidence of safety and efficacy to attract funding to push through to commercialization [ 65– 65].
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Research over the years has generated sufficient evidence to implicate areca-nut, as a carcinogen in humans [ 43, 44].
Observations in epidemiology and laboratory research have generated sufficient evidence that chronic inflammation evokes an increased susceptibility to cancer [ 87].
Generating sufficient evidence to characterize benefit/risk across a broad range of populations (pediatrics, geriatrics, genotype, ethnicity, etc). is becoming increasingly challenging.
This study was therefore designed to generate sufficient statistical evidence to rigorously evaluate the results of the IAVI and HVTN SOPs for concordance and to guide the prospective comparison or pooling of ELISpot immunogenicity assessments across laboratories within the CAVD initiative.
Note that, when m l and m q are relatively big, we may approximate 2m l −1 and 2m q −1 (sometimes even m l and m q ) to their nearest integers and still generate sufficient accuracy, as evidenced by the results shown in [12].
Systematic observations of various suburban areas with sidewalks in New Bern did not yield sufficient evidence indicating that sidewalks on their own generate pedestrian movement.
* There is little evidence that the industry will generate sufficient income from digital subscriber fees, non-print advertising or marketing services over the next year to offset stress on print volumes and pricing.
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CEO of Professional Science Editing for Scientists @ prosciediting.com