These findings help to explain the clinical efficacy of anti-CD20 therapy in most patients in clinical trials and generate a rationale for the use of anti-CD20 therapy in a broad population of MS patients.
Overall, these findings generate a rationale for the use of anti-CD20 therapy in a broad population of MS patients and show that B-cell depletion is comparable to the efficacy of more traditional T-cell-directed therapy.
These studies have generated a rationale for the use of Syk inhibitors in the treatment of crystal-induced arthritis and other autoinflammatory diseases.
While the addition of ICR62 to either afatinib or gemcitabine had no additional growth inhibitory effect compared with treatment with a single agent, a synergistic effect was observed in five of the seven human pancreatic tumour cell lines when afatinib was used in combination with gemcitabine (Table 2), thus generating a rationale for assessing such combination in vivo.
As noted in 4.2, some political liberals have sought to provide rationales showing why a liberal state should support certain relationships; these rationales generate corresponding reform proposals.
In clinical oncology the most prevalent non-surgery cancer treatments are radiation and chemotherapy, with a shared rationale to generate DNA damage (Jackson and Bartek, 2009; Tell and Wilson, 2010).
As a proof of concept, we have applied this rationale to generate a site-selectively dual labelled superfolder green fluorescent protein.
However, the aim of this pilot study was to provide novel data to support the underlying rationale and generate a sample size for a subsequent experimental trial.
The rationale to generate Col1a1 FRT-Cre-ER-T2-FRT mice was to enable whole animal ubiquitous expression of Cre-ERT2 until exposure to Flp recombinase (Fig. 1A).
The rationale to generate Col1a1 FRT-STOP-FRT-Cre-ER-T2 was that initially no cell expresses Cre-ERT2 because transcription of Cre-ERT2 is terminated by an upstream FRT-site-flanked transcription STOP cassette (Fig. 1B).
