Sentence examples for generate proof of concept from inspiring English sources
There may be specific advantages of this unique system for lumbar use, and it will generate proof of concept for lumbar as well as long constructs, as used for the treatment of deformities.
Although xenograft studies such as these are able to generate proof-of-concept data that a human tumour cell can be inhibited in vivo, they are relatively limited in their ability to model many forms of clinical toxicity, including those seen in some patients treated with PARP inhibitors such as olaparib.
The funding will allow Hackett to spend the next year or two generating proof-of-concept data to attract pharmaceutical companies as partners.
The initial work on host-derived HSPs (gp96) from tumours as cancer vaccines has now progressed through preclinical development into clinical trials, generating proof of concept [ 36, 85– 85].
This study was designed as an exploratory, hypothesis generating, proof-of-concept study.
The adenoviruses Ad.COXKi and Ad.KiCOX with the COX-2 and Ki-67 promoter driving E1 and E4 and vice versa were generated as proof-of-concept with our novel transfer vector.
Although sertraline was useful in generating the proof-of-concept of improved efficacy in mice, there could be reluctance on the part of patients and physicians to use a central nervous system drug for respiratory infections.
Although the therapy in this study was given before induction of injury, the authors generated a proof-of-concept for this approach, and hence the study is very encouraging.
Hence, replication in a larger, multi-center trial with appropriate evidence-based control intervention performed by researchers who are independent from the research group who generated the proof-of-concept, is required.
However, the capture of historical data has the limitation that targets can achieve a high ranking if many compounds have been generated during validation and proof-of-concept studies even where these eventually fail.
