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Randomization tests can be applied to data in order to generate null distributions non-parametrically.
To further characterize c30f12.4, we sought to generate null alleles using CRISPR/Cas9 technology with dual sgRNAs.
Repeated attempts to generate null mutants failed thus indicating that LdAceCS is essential for the parasite and can be selectively targeted to combat Leishmania infection.
Because the fitness function of EMD is weighted from the lower predictive error and the lower number of intervals, the attributes that do not use to create the classifier model mostly generate null cut-point.
We used null model 2 of Phylocom 4.1 to generate null communities.
To generate null communities, we created a list, outlining how many times each genotype appeared in each diversity treatment (i.e. 3, 6, or 12 genotypes).
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Intronic T-DNA insertions may generate null-alleles due to failure of proper splicing, leading to an aberrant/truncated protein (Wang 2008).
If the C-terminal prenylation motif of RAB23 were essential for function, as in other Rabs, then truncating mutations located anywhere in the gene would be expected to generate null-alleles.
The generated null space vectors are normalized vectors, which could avoid the noise amplification problem efficiently.
Finally, we generated null alleles of HP1a using optimized parameters through homology-directed repair and achieved an overall mutagenesis rate significantly higher than previously reported.
This function generates null communities by randomly assembling them from the observed species pool.
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