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Assembling the NALP3 inflammasome probably does not suffice to create inflammation, because the caspase 1 substrates pro-IL-1ß and pro-IL-18 need to be present to generate inflammation [43].
Importantly, the MPO-degraded CNTs did not generate inflammation when aspirated into the lungs of mice [ 72].
The amount of endotoxin in plasma is correlated to the inability of the patients' monocytes to generate inflammation ex vivo.
This indicates that the upstream mechanisms that generate inflammation are still functional and most likely unaffected by these treatments.
Accumulating evidence exists on the ability of ionizing radiation to modify the tumor microenvironment and generate inflammation.
11 As a result, fluid leaks out of vessels, and inflammatory cells are recruited within tissues where they generate inflammation and release additional MMPs.
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We consider these results suggest that a heightened host (innate) immune response to C. albicans in the mouse model may worsen kidney pathology by generating inflammation, rather than protecting the host.
Thus, murine models have provided compelling evidence for the dependence of PDAC initiation on intrinsically generated inflammation.
Other animal and human studies have implicated transition metals in generating inflammation and oxidative stress (Chen and Lippmann 2009; Costa and Dreher 1997; Gurgueira et al. 2002).
On the C3H background the G6PI model is also useful in investigating ankylosing spondylitis because it generates inflammation of vertebral joints followed by ankylosis after a single round of immunization.
However, the mechanical damage due to PDF instillation and the exposure of peritoneal cells to glucose degradation products (GDPs) and advanced glycation end products (AGEs) (due to the nonphysiological nature of this PDF) generates inflammation.
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