A wide variety of technologies have been exploited to generate drug delivery systems with biphasic release profiles.
Electrospinning and electrospraying are facile electrohydrodynamic fabrication methods that can generate drug delivery systems (DDS) through a one-step process.
This review will describe the nanodrugs targeted to specific components of cartilage matrix to generate drug reservoirs within the cartilage.
The prediction of the reacting atom(s) in a molecule for the major classes of biotransformation reactions is necessary to generate drug metabolites.
Mutations or fusions of both EGFR and ALK may be primary causes of cancer, whereas both the EGFR gatekeeper mutant T190M and MET may generate drug resistance.
Thus, our results indicated that doxorubicin or TGFβ1 treatment has the potential to generate drug resistant cancer cells with stem/progenitor cell features.
Thus, all our in vitro experiments indicated potential therapeutic benefits of using TβRI-KI to antagonize the doxorubicin-induced TGFβ signaling, which has the potential to induce EMT and to generate drug resistant stem-like cancer cells.
Additionally, cell-cell transmission and/or establishment of cellular reservoirs with the potential to generate drug resistant strains may be reduced, enhancing the effectiveness of current long-term ART regimens [32].
