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The overall goal of this work is to develop a rapid, accurate, and automated software tool to estimate patient-specific organ doses from computed tomography (CT) scans using simulations to generate dose maps combined with automated segmentation algorithms.
Using this automated extraction pipeline, it is possible to perform dose analysis on the >800,000 CT examinations in the PACS archive and generate dose reports for all of these patients.
Brunn provides a graphical interface for handling different plate layouts and dilution series and can automatically generate dose response curves and calculate IC50-values.
To generate dose response curves to PRO 2000 under conditions that simulate the postcoital CVL, TZM-bl cells were infected with HIV-1BaL diluted in media alone or in media containing pooled SP and mixed 1∶1 with serial dilutions of unformulated PRO 2000 diluted in pooled CVL.
Planned 3D radiation dose distributions will be digitally registered with kidney functional changes in order to generate dose response models.
The dose-pole will generate dose errors since every child population contains individuals that are either short or tall for weight.
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Transient transfection data were used with the ToxCast Analysis Pipeline (TCPL) to generate dose-response curves and estimate AC50 values55,57.
GraphPad PRISM (version 4) was used to analyze the data and generate dose-response curves.
We haven't had the need to generate dose-dependent line graphs for our qPCR studies.
Scripts were written in Jacobian and MATLAB to generate dose-response curves and figures.
Miniaturized assay volumes (< 10 μL/well) in a 1536 well-plate format provide the high-throughput required to generate dose-response data for every compound library member tested.
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