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Should this prove to be the case, it would, if nothing else, at last confirm the grim mystique that alcohol can generate disease.
Very recently, Wang et al. used TALEN technology to modify the three homoeo-alleles of MLO in hexaploid bread wheat.46 Gain-of-function mutants exheritableitable resistance to powdery mildew, and this highlights the potential application of genome-editing technologies in the modification of the MLO alleles in horticultural crops to generate disease resistant varieties.
Such experiments can be used to study human development, generate disease models, and potentially grow human organs for transplantation.
However, despite decades of extensive research designed to uncover the cellular and molecular mechanisms that generate disease, the precise etiology of NEC remains elusive.
Subsequent studies demonstrated that human induced pluripotent stem (hiPS) cells could be generated using the same or slightly different sets of reprogramming factors, offering the possibility to generate disease- or patient-specific stem cells [3], [4], [5], [6], [7], [8], [9], [10].
Using such an approach requires established gene disease associations to use those to generate disease and gene profiles.
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In this study, we successfully reprogrammed RA FLSs and OA FLSs to generate disease-specific iPSCs.
One approach for developing molecular connectivity map data is to generate disease-specific protein-drug association profiles computationally by mining bio molecular interaction networks and PubMed literature [ 15].
As the discovery samples used to generate disease-specific GRPS increase, the scores become more powerful with respect to both disease-linked risk alleles and disease-linked exposures.
This seminal finding set the stage to generate disease-specific human iPSC from patients' somatic cells (Park et al, 2008; Yu et al, 2007).
In this study, we employed Solexa sequencing of pooled sera samples followed by multiple RT-qPCR verification assays of individual samples to generate disease-associated serum miRNA profiles.
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