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Since the IMP cells described in this study failed to generate derivatives of LM, we reasoned that these cells may differentiate into cell populations derived from IM, such as kidney and gonads.
Proteins can also be combined with a wide range of drugs to generate derivatives with tailored pharmacological properties.
Combinatorial biosynthesis approaches are being used in antibiotic-producing actinomycetes to generate derivatives with novel sugars in their architecture.
Pluripotent stem cells are characterized by their ability to expand indefinitely in vitro while retaining the capacity to generate derivatives of all three germ layers, both in vitro and in vivo.
The mechanisms that drive the differentiation of HESC when grown in suspension as EBs still remain largely unknown, but typically under these conditions the cells spontaneously generate derivatives of all three primary germ layers [28].
These CEN-based plasmids were used to obtain the data in Fig. 3B,C and D. To integrate mad3 mutants into the genome, we excised a PmlI-EcoRI fragment (containing CEN4, ARS1 and TRP1) from these mutant plasmids and replaced it with a PmlI-EcoRI fragment from YIplac204 (containing TRP1) to generate derivatives that could be targeted to the TRP1 locus following linearization with BsgI.
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These philosophers employed these two principles, according to Aristotle, to generate derivative entities (substances, beings) of other types: Forms, numbers, and so on.
Virtually, all current FTIR spectrometers generate derivative spectra by mathematical means.
Our recent work showed that the P1-ovov454 allele undergoes RET to generate derivative alleles containing either deletions or Tandem Direct Duplications (TDDs; Figure 1 figure supplement 1).
This strategy is certainly very useful for understanding bacterial evolution, such as pathogen emergence, adaptation to environmental perturbations or during fermentation events used to generate derivative strains with enhanced industrial capacities [ 3- 5].
Anatomy of body structures such as innervation, origin, and/or insertion of muscles of the arm, for instance, seems to be not random in animals that evolved from a common ancestral animal, since the ancestral animal provided basic structures and could generate derivative features in descendant animals (for a detailed review, see [ 2]).
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