Sentence examples for generate cortisol from inspiring English sources

Impairment in the ability of the inflamed synovium to generate cortisol has been proposed to be a factor in the persistence and severity of inflammatory arthritis.

Moreover, it might facilitate development of new antiinflammatory therapies, for example, encapsulated delivery of cortisone to the site of inflammation to take advantage of local 11β-HSD1 actovity to generate cortisol within the tissue in which it will be of most benefit, thus limiting the adverse metabolic effects of whole-body exposure to exogenous synthetic glucocorticoids.

Cortisone reductase deficiency (CRD) and apparent CRD (ACRD) are characterised by the failure to generate cortisol from inactive cortisone resulting in HPA axis activation and excessive ACTH-mediated adrenal androgen secretion, with ∼14 cases described clinically and biochemically in the literature (1, 2, 3, 4, 5, 6, 7, 8, 9).

Based on the divergent effects of 11 βHSD-1 and -2 on cell proliferation observed in vitro, Rabbitt et al (2003) have previously suggested that the ability of 11 βHSD-1 to generate cortisol might act as an autocrine antiproliferative, prodifferentiation stimulus in normal adult tissues.

The task now, he adds, is to sort out to what extent a dampened response to stress is ruled by genes and to what extent by early emotional trauma, which can permanently alter the hormonal system that generates cortisol.

Administration of this modified-release preparation generates a plasma cortisol profile that mimics the natural diurnal pattern of circulating cortisol, except for the early morning increase in cortisol that occurs during sleep [ 25].

Cortisol generates a physical response to the stress signal by binding to its cytoplasmic receptor, GR, and promoting protein, lipid, and carbohydrate catabolism [ 35, 36].

Additionally, intracellular cortisol, generated from cortisone secondary to the activity of 11 betahydroxysteroid dehydrogenase 1 enzyme, can diffuse into the interstitium [ 15], thus contributing to the interstitial pool of free cortisol.

The treatments were supposed to generate different levels of engagement and cortisol responses, because some of them were designed for a single user, while others were team-based, featuring so-called social-evaluative threat (ST) components.

LKO mice were able to regenerate approximately 35 40% of the cortisol that control mice generate, despite hepatic loss of 11β-HSD1 (control, 1800 ± 125 n m vs. LKO, 650 ± 87 n m), whereas HSD1KO were unable to regenerate cortisol (Fig. 2A); 10- and 30 min bleeds after cortisone acetate gavage gave similar relative results (data not shown).

Together, these data will generate valuable insights into the benefits of different cortisol replacement therapies in routine clinical practice.