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Open image in new window Fig. 3 An example of Paxos members' information used to generate committed LSN.
Given the stem cell-like properties of ESP cells as presented here and reported elsewhere [5], [6], it is tempting to speculate that ESP cells may generate committed progenitor cells through asymmetrical cell division, which, in turn, may lose the SP phenotype, further behave as transient amplifying cells, and eventually propagate through symmetrical cell division.
It relies on small populations of specified precursor cells that expand and generate committed cells, which ultimately differentiate into myocytes.
By dividing asymmetrically, cancer stem cells maintain the stem cell pool and simultaneously generate committed cells that form tumor mass [ 32].
Adult tissues retain a small subset of resident undifferentiated stem cells that can self-renew asymmetrically to generate committed progenitors for the replenishment of the different cellular phenotypes that are lost during normal tissue turnover.
We here observe that the inability of FOG-1-deficient HSCs to generate committed Mk/E progenitors is associated with their loss of preMegE-specific gene expression and upregulation of preGM-associated genes.
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The development and maintenance of most tissues and organs requires the presence of multipotent and unipotent stem cells that have the ability of self-renewal as well as of generating committed, further differentiated cell types.
We now show that these cells are ER–, but they give rise to ER+ cells, which in turn can generate cells committed to the luminal lineage.
We also demonstrate in functional assays in vitro and in vivo that ALDE+/ER– mammary stem/progenitor cells give rise to ER+ progenitor cells, which in turn can generate cells committed to the luminal lineage.
Get committed.
More than 18 quintillion of them, goes the marketing behind No Man's Sky, procedurally generated and committed to disk for everyone to slowly pull apart.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com