We attempted to generate a physicochemically stable cholera toxin B subunit (CTB) by de novo-introduction of intersubunit disulfide bonds between adjacent subunits.
Our final ZINB model (Table 2) was selected on the basis of strong goodness of fit and conformity to our theoretical sense of the underlying process generating the baris' cholera counts.
This study was aimed at isolating and characterizing V. cholerae strains from water sources in Bepanda, determining the susceptibility of isolates to antibiotics and evaluating some physico-chemical parameters that could be supporting the survival of the organism in this locality, so as to generate information that could be exploited for cholera prevention and management.
We analyzed the influence of some factors on the bacteriological quality of well water in Bepanda and New Bell, cholera endemic localities in Douala to generate data that would serve as basis for strengthening of water and health policies.
In an effort to develop a mucosal vaccine, a modified cholera toxin gene was genetically linked to the C. trachomatis MoPn NiggII MOMP gene to generate a recombinant protein with the mucosal adjuvant properties of the cholera toxin and immunological antigenicity of the chlamydial protein.
Vibrio cholerae can express a T4P-like system and generate toxin co-regulated pili.
However, the possibility of the occurrence of the organism in this state in study area has to be considered in future studies, to generate comprehensive data on the occurrence and persistence of V. cholerae in study area.
Ten key messages around cholera vaccination and cholera prevention were generated and shared during the campaign via radio shows, sound trucks (local vehicles with megaphones), T-shirts, posters, and local television.
Bacterial toxins and their derivatives Cholera toxin (@cholera vaccines), Heat-labile enterotoxin** PAMP, bind to GM1 gangliosides receptors on mucosal cells, generate potent and broad immune response, serve as gold standards for adjuvant potency investigation, show the safety issue of causing facial paresis after intranasal administration.
The PFGE pattern generated by the V. cholerae O1 strains in this study also matched with the pattern reported for V. cholerae O1 associated with cholera outbreaks in Bangladesh and Haiti, suggesting that closely related multi-drug resistant strains are undergoing global dissemination.
