Metabolic overload triggers oxidative stress, organelle dysfunction, and cell hypertrophy, all of which generate a vicious self-amplifying cycle that leads to inflammation [ 1].
Heavy traffic, when the irregularities of the road surface evolve toward significant values of deterioration, generates a considerable dynamic overload, closely connected with the accelerations of the great masses of trucks.
The ability of PAC-1 to induce MAM-dependent ER calcium leakage into the mitochondria, generating a calcium and ROS overload at the mitochondria, could drive PUMA-dependant mitochondrial permeabilization independent of Bax/Bak.
Use of these solutions reduces the risk of hyponatremia, but excessive absorption can, as with monopolar current, lead to expansion of the extracellular fluid volume with the potential to generate fluid overload, pulmonary oedema, hypertension and cardiac failure.
In a setting of ischemia, or reoxygenation of ischemic tissue, reverse-mode NCX can generate Ca overload, leading to necrotic myocyte death (9).
Data from in vitro studies show that CPVT-associated RyR2 and CASQ2 mutations 8 49 cause cytosolic Ca2+ overload which generates a net inward current.
These criteria were described particularly in relation to internet-based safety netting resources: currently, searching the internet generates an 'overload' of information, some of which are not useful, which creates uncertainty and anxiety among parents.
Both circumstances give rise to un-supplied demand at certain stations, which generate passenger overloads in the available vehicles.
The aortic banding model was used to generate pressure overload-induced hypertrophy and heart failure.
