These findings are particularly interesting since FBs are also an important source of natriuretic peptides, and as such can generate a negative feedback loop [ 127].
Mechanistic studies reveal that BAs generate a negative feedback on ASBT expression by FXR-mediated induction of SHP, which binds to and represses the transcriptional activities of LRH-1 for the Cyp7a1 gene.
Several previous reports confirmed that the E2F transcription factor family members can induce the expression of miR-17-92 miR-17-92 miR-17-92andly members are directwoargets of miR-17-92, which generathesenegative familyck loop aimembersrestricting miR-17-92 trarecription levels.
Writing the resume rather than outsourcing is a costly endeavor that generates a negative feedback loop of underperformance, irregular work/life balance, Type A managers, positions with unrealistic expectations, toxic work environments, and less compensation for work performed.
They may be influenced by the high-profile parochialism of their predecessors: Ian Rush, himself a Welshman, infamously characterised the year he spent in Italy in 1988 with the truism that "it was like living in a foreign country".What is clear is that such sentiments have generated a negative feedback loop, which ensures that most English players stay at home.
Binding of RsaL to the bidirectional rsaL-lasI promoter inhibits the expression of both genes, which generates a negative feedback loop that counteracts the positive signal feedback loop mentioned earlier, thereby balancing the levels of OdDHL (Rampioni et al., 2007).
HP1c in contrast impairs the ability of Woc to stimulate transcription from the endogenous HP1c locus, thereby generating a negative feedback loop that ensures a balanced level of Woc and HP1c in vivo.
Thus, in the normal gastrointestinal tract, HH ligands are induced in the differentiated cells around the villous surface, generating a negative feedback loop to inhibit canonical WNT signaling in the basal cells of the crypt, thereby protecting differentiated cells from the proliferative effects of WNT [13].
In other words, Aurora B/C kinase creates its own inhibitor, generating a negative feedback loop.
Circadian clocks in peripheral organs are controlled by the interplay between transcriptional activators and repressors, which generates a negative feedback loop of core clock gene expression.
When internal phosphate is low, the PHO pathway is activated, Pho4 is dephosphorylated, and stimulates expression of Pho84, resulting in higher phosphate uptake, generating a negative feedback loop.
