Following sequencing, the reads are typically aligned with a reference genome or transcriptome or assembled de novo to generate a base-resolution expression map for each gene at the transcriptional structure level and/or expression level.
The goal of this integrated approach is to generate a knowledge base for improving clinical and field management of malaria.
In the context of a pilot study, this comprehensive scan of the keloid methylome was attempted as an initial proof of concept to generate a knowledge base for insight into the biological complexity of keloids from a genome-wide promoter methylation perspective.
Our interview study formed part of a wider service development project conducted in London, UK, which aimed to develop a social outreach model of care for marginalised groups with TB and generate an evidence base for the need of a TB caseworker in supporting clients with complex needs and is reported elsewhere [ 19, 20].
University academics generate an evidence base for public policy [ 117] and can facilitate the passage of new research knowledge into the evidence base of concrete policies.
The goal of the program is to probe the enduring challenge of female educational disadvantage in India in order to generate an evidence base for enhancing the access of disadvantaged girls to education and to the social, economic and psychological benefits that this education is known to bestow.
The first objective is to conduct in-depth interviews of HIV+ patients who have been diagnosed with cancer to identify themes that will generate an evidence base for care-seeking behavior.
The findings will help determine both the proportion of chronic PPH admissions that are deemed preventable, and the modifiable drivers contributing to preventable admissions, and will thus help generate an evidence base for the development and targeting of interventions to reduce chronic PPH admissions.
The National Institute for Clinical Excellence ('NICE') guidelines appear to be more accurate than those of the Scottish Intercollegiate Guidelines Network ('SIGN') in defining 'moderate' familial risk, and longer follow-up of this cohort could generate an evidence base for further modification of familial breast cancer services.
For paired-end data, alignments corresponding to both reads in the pair are considered together to generate a single base pattern for the pair.
