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This explains at least in part the different behavior of the two strains in a Golden Syrian hamster model of acute disease [ 22], as animals are generally sensitized to C. difficile with a clindamycin treatment (ermB is an rRNA adenine N-6-methyltransferase that also confers resistance to clindamycin).
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Together these data suggest that a reduction of HuR expression by siRNA generally sensitizes adenocarcinoma cells towards stimulus-induced apoptosis without affecting the basal rate of apoptosis.
Given the observation that resistance to cDDP was linked to lower intracellular ROS levels and that high levels of ROS are generally detrimental to cells, we next sought to determine whether addition of emodin, a well-known ROS generator, could sensitize the cDDP-resistant COC1/DDP cells to the cytotoxic effects of cDDP.
While such analyses are interesting (e.g. immunizing with low doses of ovalbumin in alum predisposes to Th2 responses, while higher doses predispose to Th1 responses [34]), they generally may not represent how humans are sensitized during the development of asthma.
In a mouse model of airway inflammation, in which mice were sensitized with OVA and then challenged with OVA, treatment with dexamethasone generally attenuated airway inflammation.
By contrast, there are generally no "safe" exposure levels for agents to which workers and others have been sensitized; avoidance of further exposures often requires a change in job function or occupation.
The specificity of CHS response is generally defined as the difference between ear swelling responses to a given hapten dose in naïve versus sensitized animals [14] mediated by T-cells.
Because tumor cells generally have higher levels of ROS than do normal cells, they are under conditions of increased oxidative stress and are sensitized to death by ROS-promoting agents.
They were sensitized.
Imagine if the world were sensitized in this way.
We live in a highly sensitized global village.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com