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Because study population consisted of patients generally pretreated with systemic therapy, chemotherapy doses slightly lower than standard were used for both chemotherapeutic agents.
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They were generally heavily pretreated, having received a median of 8 non-chemotherapy, and 2 chemotherapy-based treatment modalities before being transplanted.
In spite of the patients generally being heavily pretreated, some evidence of disease stabilisation was seen, and seven patients demonstrated SD after 6 weeks of treatment.
Nakagame et al. have previously compared steam explosion and organosolv pretreatment of three different substrates, and their results also generally showed that organosolv pretreated substrates adsorbed more protein from commercial cellulases compared to steam exploded substrates [ 21].
Generally, when biomasses are pretreated, the phenolic substances are derived and released from lignin.
Enzymatic saccharifications were performed on the ammonia hydroxide pretreated biomass by generally following the published procedure in NREL technical report NREL/TP-510-42629 [57].
It is also important to note that chips pretreated for longer times generally exhibited higher yields for all sub-samples, as expected.
In contrast, mice pretreated with the Reg3b Glp-1 vector generally showed apparently healthy islets with sustained insulin-positive β-cells (Fig. 3A,B).
Generally, the compositions of the corn stover samples pretreated in the three reactors were similar.
TB-403 was generally well tolerated in this small population of heavily pretreated patients with advanced solid tumours.
Although generally reversible, prolonged suppression and sepsis were responsible for the deaths of 3 heavily pretreated patients.
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