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Generally, normalization is intended to modify the underlying data as slightly as possible, but as much as necessary to remove systematic biases yet to conserve biological relevant information.
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"There are a lot of single-family households, lots of poverty, gang activity, drugs and generally, a normalization of violence in these communities," DiVittorio said.
More generally, this normalization procedure, detailed in the following paragraphs, was designed to yield firing rate estimates that were robust over wide ranges of spiking activity.
Generally, a normalization method should modify the original data as little as possible.
Because the average β is the measurement within a sample and the two probe signals at a particular CpG are reported by the same dye, it is generally believed normalization is not necessary.
Relative radiometric normalization generally suffers from cloud covers, while multi-temporal cloud detection is sensitive to the radiometric normalization quality.
More generally, relaxing the normalization of h0 and h1, this can be expressed as Ith = G1P T /(40G0).
Then, generally, a proper normalization algorithm is used to estimate expression levels for comparative analyses.
Generally speaking, cDNA normalization is often used when gene discovery is the primary purpose of sequencing.
This LOESS normalization generally involves two steps [ 23]: (1) select probes (or genes) used to do normalization, and (2) apply a LOESS or weighted LOESS to the data.
Unfortunately, the nature of the distribution of gene expression is generally unknown and normalization methods that are independent from this variable are desirable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com