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Failure to identify infections with these types at baseline would have resulted in an underestimation of the protective effect against any disease in the generally naive population.
As expected, the proportion of disease prevented in generally naive subjects was similar but slightly lower than the proportion of cases found to contain the DNA of these viruses (30% of cervical intraepithelial neoplasia grade I, 83% of condyloma).
Vaccine efficacy against any lesion (regardless of HPV type) in the generally naive population was 30%17%to41o 41%, 755%22%to94% 94%), and 48%10%to71% 71%) for cervical, vulvar, and vaginal intraepithelial neoplasia grade I, respectively, and 83% (74% to 89%) for condyloma.
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The public, innocent and not so innocent, is generally quite naive about just how law enforcement personnel (and lawyers in litigation) ply their trade, to their own advantage.
We would spend too much time the rest of that year being overly timid with our Spanish, stressing about surprisingly challenging classes, pining over boys back home that didn't deserve us, finding comfort in McDonald's €1 ice cream cones, complaining about dreary weather, and generally being naive college students.
Intention to treat, generally HPV naive, and unrestricted susceptible populations were also studied.
The box lists the criteria and rationale for the analysis populations considered in this report (per protocol susceptible, intention to treat, generally HPV naive, and unrestricted susceptible).
The vaccine efficacy against condyloma in generally HPV naive women of 83% thus corresponds to a potential reduction in absolute yearly incidence of condyloma of 0.83%.
In this study we measured vaccine efficacy against disease related to specific HPV type and against disease regardless of HPV type, enabling an estimate of the total gains in reduced disease burden after vaccination of generally HPV naive women.
Limitations of the current analyses include the fact that the generally HPV naive population was tested only for the presence of the four vaccine HPV types and 10 other HPV types prevalent in cervical cancer.
Vaccine efficacy against any cervical intraepithelial neoplasia grade I (regardless of HPV types present) was 30%17%to41% 41%) in the generally HPV naive population (241 cases in vaccine group v 346 in placebo group) and 20%12%to28% 28%) in the intention to treat population (788 v 984 cases) (table 5).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com