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However, finding or predicting such hub proteins remains a challenging task as the corresponding experiments are very costly, while traditional bioinformatics approaches generally fail in forecasting PIN data due to the general lack of agreement between the existing datasets [1].
The results have pointed out that lumped models generally fail in predicting the wall temperature profiles (i.e. the light-off position).
Bigotry is both pathetic and foolish and bigots generally fail in the marketplace extensive systems of discrimination like Jim Crow and Apartheid have to be imposed by a racist government in order to stay in place.
In pharmaceutics, drugs generally fail in the clinic for two reasons: they either do not work or are proved to be unsafe [ 1].
A corollary to this perspective is that hatchery programs, particularly hatchery augmentation and supplementation programs which have been the main focus of the debate, generally fail in their objective of maintaining fitness and of contributing to the natural productivity of wild salmonid populations (Reisenbichler and Rubin 1999; Fleming and Petersson 2001; Reisenbichler et al. 2003).
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The specimens generally failed in two modes, namely bar fracture and bond-slip failures.
The vertically built samples generally failed in a transgranular mode while the horizontally built samples failed in an intergranular mode.
Longer span decks generally failed in bending, whereas shorter span decks suffered from local shear failure at the corner of the tubes.
Health Information Exchanges (HIEs) have generally failed in this regard, lasting only as long as the subsidies and mandates that prop them up.
Despite small successes and even major milestones over the subsequent 20 COPs, or conferences of the parties -- including approval in 1997 of the Kyoto Protocol, the first global agreement for mandatory reductions in greenhouse gas emissions -- the annual gatherings have generally failed in their chief objective to stabilize the warming of the atmosphere.
It can be clearly seen that when considering crowded subtomograms without excluding surrounding structures, our previous method (Xu et al., 2012) generally fails in finding the correct alignment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com