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The enrichment analysis of GO and KEGG showed that the prioritized genes were generally enriched for biological processes related to apoptosis and programmed cell death and for pathways associated with cancers.
A number of studies have demonstrated that co-expression network modules are generally enriched for known biological pathways, for genes that are linked to common genetic loci and for genes associated with disease [6], [7], [11], [13], [14], [15], [40], [41], [42].
One important end product of GCENA is the construction of gene modules comprised of highly interconnected genes, and a number of studies have demonstrated that co-expression network modules are generally enriched for known biological pathways, for genes that are linked to common genetic loci, and for genes associated with disease [24] [32].
Whether CBP/p300-independent target genes are generally enriched for other types of coactivators remains to be established.
The TF-encoding genes that are involved in nervous system development are generally enriched for human-fugu CNEs.
These repressed genes are generally enriched for H3K9me2 or H3K27me3, especially when they have high or intermediate CpG density, respectively.
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In addition, the GR pathway was also generally enriched in the genes/proteins identified for Cr, Ni, and Pb.
For example, D3 dopamine receptors are generally enriched in the viscerolimbic striatum and extended amygdala in normal conditions, and their number is increased in schizophrenics (Joyce and Gurevich 1999).
The loss-of-function mutants in kinases were generally significantly enriched for essential phenotypes (p = 0.020, Fisher's Exact Test), cellular and biochemical phenotypes (p < 0.001, Fisher's Exact Test) as well as for conditional phenotypes (p = 0.002, Fisher's Exact Test) compared to loss-of-function mutants in non-kinase genes.
Groundwaters impacted by mature landfill leachate are generally enriched in ammonium.
In mouse cells these areas are generally enriched in the H3K9me3 histone PTM [8], [51].
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