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Mutations in the region 1 21 are tolerant to changes without the loss of biologic activity; in contrast, changes in amino acids 25 40 are generally deleterious for transactivation.
These negative results show that laser tissue interactions are not generally deleterious for respiratory function in vitro (Eklöf-Ljunggren et al., 2012; Wang et al., 2013).
Remarkably, functionally important viral categories presented composite genes, even though changes in such key genes may be generally deleterious for their viral hosts.
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The mutations caused in cells by this radiation are generally deleterious.
Naan bread, like pasta, offers little from a nutritional perspective and will have, particularly when eaten in quantity, generally deleterious effects on the body's biochemistry.
Disruption of no other drug pump was generally deleterious.
Since Mg2+ is known to be an effective blocker of certain Ca2+ channels [31], [32], this could have a generally deleterious effect on neurotransmission.
Mutation is generally deleterious, at least in natural conditions (Keightley and Lynch 2003).
The aneuploidy phenotype seems paradoxical given that aneuploidy is generally deleterious (Niwa et al., 2006).
Some mutations that reduce one fitness component may do so because they are generally deleterious.
Kirkpatrick and Barton's theory was a significant advance in our expectations for the evolutionary dynamics of inversions, which previously assumed that they would be generally deleterious due to meiotic imbalance or disrupted genes at the breakpoints (Kirkpatrick 2010).
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