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Searches against control proteomes of free-living eukaryotes served as negative controls to exclude proteins that are generally conserved across phyla, while searches with random sequences allowed to estimate statistical significance.
In contrast to the two-loop model, the robustness analysis demonstrated that the model is extremely sensitive to a specific minor group of parameters, which are generally conserved across all reference parameter sets.
False positive hits can be tracked by including the appropriate controls: proteomes of free-living species to eliminate the proteins which are generally conserved across phyla, and scrambled versions of the parasite proteomes to estimate for random hits resulting from the sheer number of analyzed sequences.
The exon patterns were generally conserved across vertebrates.
Likewise, at sequence level, it appears that these half EREs are generally conserved across primates.
A lack of methylation of mitochondrial and chloroplast tRNAs was generally conserved across diverse plant species.
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Secondary structure topologies are mostly conserved across the four binding proteins considered here.
Figure 2a shows that, despite the difference in assembly size, gene-level synteny is generally conserved with P. JDR2 across the entirety of many P. larvae contigs.
The generally conserved structures of antimicrobial peptides, across a wide variety of organisms, lend some clues as to their mechanisms of action.
The DNA methylation pattern is generally conserved, and through comparative analyses of DNA methylation across mammalian species, it has been suggested to play a role in tissue-specific gene regulation [ 20].
Many of the genes involved in PEV turned out to have a critical role in gene silencing across the genome, and their functions are generally conserved between eukaryotes (Fodor et al. 2010).
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