New daily insertions of catheters to avoid any local thrombus formation, however, are not feasible under clinical conditions due to hemodynamic instability, generalized edema formation related to capillary leakage, and a limited number of accessible vessels.
Alders, M. et al. Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans.
We find that mice with disruptions of both NFATc4 and the related NFATc3 genes die around E11 with generalized defects in vessel assembly as well as excessive and disorganized growth of vessels into the neural tube and somites.
Accordingly, increased vascular leakage was observed in the inflamed skin of Vasp−/− mice [18] and mice deficient in Mena, Vasp, and EVL develop spontaneous and generalized edema due to severe vessel texture defects [20].
These data suggest a BsMAb-induced lymphocyte adhesion to blood vessel walls and/or generalized redistribution of the lymphocytes into tissues.
Arterial bleeding requires more specific pressure on the bleeding vessel than the generalized pressure used for venous-type bleeding.
In other words, generalized inflammation that damages blood vessels can potentiate or aggravate diseases such as atherosclerosis and stroke.
This series of specializations has increased the efficiency with which water moves through the vessels: from the more generalized method of water diffusion through pit membranes of narrow tracheids to mass movement of water through the perforated end walls of relatively narrow scalariform vessels and then to relatively wide simple vessels with large single perforated end walls.
Other clinical features include tightly adherent thin skin, prominent vessels, characteristic facial features, generalized joint contractures, dysplasia of clavicles and respiratory insufficiency.
Almost twenty years ago, in Volume 2 of Reliability Engineering (the predecessor of Reliability Engineering and System Safety), a paper by H. M. Thomas of Rolls Royce & Associates Ltd. presented a generalized approach to the estimation of piping and vessel failure probability.
